Maier W, Hallmayer J, Lichtermann D, Philipp M, Klingler T
Department of Psychiatry, University of Mainz, Federal Republic of Germany.
Eur Arch Psychiatry Clin Neurosci. 1991;240(6):355-62. doi: 10.1007/BF02279766.
The endogenous/non-endogenous distinction of unipolar major depression is widely accepted, as is the family study approach to the validation of diagnostic distinctions. Rates of affective disorders were examined in 689 first-degree relatives of 184 patients with unipolar major depression and were compared with 312 first-degree relatives of 80 healthy controls. Only unipolar depression and alcoholism were more common in families of depressed probands compared with families of healthy controls. As a variety of diagnostic definitions of endogenous depression have been proposed, probands and relatives were diagnosed in a polydiagnostic manner. None of the five diagnostic definitions of endogenous depression was able to identify patients with an increased familial risk of unipolar depression.
单相重度抑郁症的内源性/非内源性区分已被广泛接受，用于验证诊断区分的家族研究方法也是如此。对184例单相重度抑郁症患者的689名一级亲属的情感障碍发病率进行了检查，并与80名健康对照者的312名一级亲属进行了比较。与健康对照者的家庭相比，只有单相抑郁症和酗酒在抑郁症先证者的家庭中更为常见。由于已经提出了多种内源性抑郁症的诊断定义，因此对先证者和亲属进行了多诊断方式的诊断。内源性抑郁症的五种诊断定义中，没有一种能够识别出单相抑郁症家族风险增加的患者。
