Heidelberger M, Bernheimer A W
Proc Natl Acad Sci U S A. 1984 Aug;81(16):5247-9. doi: 10.1073/pnas.81.16.5247.
Cross-reactions of a number of glycans and polysaccharides isolated from fungi, molds, and yeasts in anti-pneumococcal and other antisera are tabulated and discussed insofar as possible with relation to the chemical structures of the cross-precipitating substances and the polysaccharidic antigens giving rise to the reactive antibodies. For example, the slime of Physarum polycephalum precipitated antisera to pneumococcal type 4 and Klebsiella type K1. The polysaccharides of type 4 and K1 contain pyruvic acid in acetal linkage on hydroxyls 2 and 3 of sugars. Therefore, pyruvic acid was looked for and found in Physarum slime. Numerous other relations between chemical structure and immunological specificity are given.
列出了从真菌、霉菌和酵母中分离出的多种聚糖和多糖在抗肺炎球菌血清及其他抗血清中的交叉反应，并尽可能结合交叉沉淀物质和产生反应性抗体的多糖抗原的化学结构进行了讨论。例如，多头绒泡菌的黏液能使抗肺炎球菌4型和肺炎克雷伯菌K1型的血清发生沉淀。4型和K1型的多糖在糖的2位和3位羟基上含有缩醛键连接的丙酮酸。因此，在多头绒泡菌黏液中寻找并发现了丙酮酸。还给出了化学结构与免疫特异性之间的许多其他关系。
