Goodwin J S, Ceuppens J L, Rodriguez M A
Inflammation. 1984 Jun;8 Suppl:S49-55. doi: 10.1007/BF00915712.
The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0 micrograms/ml), carprofen (10 micrograms/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.
使用吲哚美辛（5.0微克/毫升）、卡洛芬（10微克/毫升）研究了非甾体抗炎药（NSAIDs）对体外IgM类风湿因子产生及体内血清类风湿因子浓度的影响。IgM类风湿因子从类风湿关节炎患者的淋巴细胞中分离得到。非甾体抗炎药在体外抑制IgM类风湿因子的产生。此外，体内给予非甾体抗炎药时，血清IgM类风湿因子降低。据认为，非甾体抗炎药有效地消除了PGE2的强直性抑制作用中的抑制性T细胞。非甾体抗炎药这种以前未被认识的作用可能是它们对类风湿关节炎疗效的一个因素。
