Brogden R N, Heel R C, Speight T M, Avery G S
Drugs. 1984 Oct;28(4):292-323. doi: 10.2165/00003495-198428040-00002.
Piroxicam is a chemically different non-steroidal anti-inflammatory drug with a long half-life which enables it to be administered once daily. This member of the oxicam series of compounds is now well established in the treatment of rheumatoid arthritis and osteoarthritis and has been shown to be a suitable alternative to aspirin, indomethacin, naproxen, ibuprofen, ketoprofen, sulindac, phenylbutazone and diclofenac in the treatment of rheumatic diseases. Open trials in many thousands of patients in hospital clinics and in general practice have demonstrated its analgesic and anti-inflammatory efficacy in a wide cross-section of patients with rheumatic diseases, when administered once daily either at night or in the morning, and recent studies have demonstrated its usefulness in musculoskeletal disorders, dysmenorrhoea and postoperative pain. Such studies have also demonstrated the generally good tolerability of piroxicam 20mg daily. As with other non-steroidal anti-inflammatory drugs, gastrointestinal complaints are the most frequently reported side effects. The frequency and severity of these effects are dose related. Thus, piroxicam is now well established in the treatment of rheumatic diseases and offers an alternative to other analgesics in various pain states.
吡罗昔康是一种化学结构不同的非甾体抗炎药，半衰期长，可每日给药一次。这种氧杂蒽类化合物现已在类风湿性关节炎和骨关节炎的治疗中得到广泛应用，并且已证明在治疗风湿性疾病方面，它是阿司匹林、吲哚美辛、萘普生、布洛芬、酮洛芬、舒林酸、保泰松和双氯芬酸的合适替代品。在医院诊所和普通医疗中对数千名患者进行的开放试验表明，当每天晚上或早上给药一次时，它对广泛的风湿性疾病患者具有镇痛和抗炎功效，并且最近的研究表明它在肌肉骨骼疾病、痛经和术后疼痛方面也有用处。这些研究还表明，每日服用20mg吡罗昔康通常耐受性良好。与其他非甾体抗炎药一样，胃肠道不适是最常报告的副作用。这些副作用的频率和严重程度与剂量有关。因此，吡罗昔康现已在风湿性疾病的治疗中得到广泛应用，并为各种疼痛状态下的其他镇痛药提供了一种替代选择。
