因异常易位导致的“隐匿性”费城染色体（Ph1）

"Masked" philadelphia chromosome (Ph1) due to an unusual translocation.

作者信息

Marinello M J, Morita M, Sandberg A A

出版信息

Cancer Genet Cytogenet. 1981 Apr;3(3):227-32. doi: 10.1016/0165-4608(81)90088-1.

Abstract

The case of a 58-year-old white female with Philadelphia (Ph1)-positive chronic myelocytic leukemia (CML) and a "masked" Ph1 chromosome is described. The Ph1 was due to a translocation involving chromosomes #12 and #22, in which most of the long arm of #12 had been translocated to the deleted #22 (Ph1). The necessity of performing banding analysis in those cases of CML where a Ph1 is not readily apparent is stressed and the literature on"masked" Ph1 chromosomes is briefly summarized.

摘要

本文描述了一例58岁白人女性费城（Ph1）阳性慢性粒细胞白血病（CML）患者，其存在一条“隐匿”的Ph1染色体。该Ph1染色体是由于12号和22号染色体发生易位所致，其中12号染色体的大部分长臂已易位至缺失的22号染色体（Ph1）上。强调了在那些Ph1染色体不易显现的CML病例中进行显带分析的必要性，并简要总结了关于“隐匿”Ph1染色体的文献。