Moroni C
Schweiz Med Wochenschr. 1984 Oct 6;114(40):1369-73.
Retroviral oncogenes are derived in evolution from normal cellular genes termed proto-oncogenes. This discovery has prompted the question whether human tumor cells show alteration of proto-oncogenes. Alteration found in leukemias (gene amplification, translocation and point mutation) are briefly discussed. The genes termed myc, abl, ras are involved. A case of acute myeloblastic leukemia with a point mutation in the N-ras gene is briefly discussed.
逆转录病毒癌基因是在进化过程中从称为原癌基因的正常细胞基因衍生而来的。这一发现引发了一个问题，即人类肿瘤细胞是否显示原癌基因的改变。本文简要讨论了在白血病中发现的改变（基因扩增、易位和点突变）。涉及到称为myc、abl、ras的基因。本文还简要讨论了一例N-ras基因发生点突变的急性髓细胞白血病病例。
