Nordenskjöld F, Fex S
Acta Obstet Gynecol Scand Suppl. 1984;123:131-2. doi: 10.3109/00016348409156999.
Vocal effects of danazol therapy were studied in 23 women. Before danazol therapy was started the patients were examined by a phonitrician using indirect laryngoscopy and microlaryngoscopy in stroboscopic light. A glottographic frequency indication ad modum Kitzing and a tape-recording were also made. These examinations were carried out again after 3 and 6 months of therapy. The patients mostly received 600 mg danazol daily. One of the patients noticed a very marked change in her voice after 2 weeks of therapy. This patient also had conjunctivitis and the reaction was judged to be an allergic reaction to the drug and not a hormonal side effect. In 4 of the other 22 patients the glottographic frequency indication showed a slight decrease in the mean frequency and in 3 a slight increase within the normal range of interpersonal variation. None of the patients noticed subjectively any virilization of the voice. In this preliminary study we have not found any significant vocal changes in the 23 patients tested that could be attributed to the androgenic properties of danazol.
对23名女性进行了达那唑治疗对嗓音影响的研究。在开始达那唑治疗前，由耳鼻喉科医生使用间接喉镜和频闪喉镜下的显微喉镜对患者进行检查。还进行了Kitzing模式的声门图频率指示和录音。治疗3个月和6个月后再次进行这些检查。患者大多每天服用600毫克达那唑。其中一名患者在治疗2周后注意到自己的声音有非常明显的变化。该患者还患有结膜炎，这种反应被判定为对药物的过敏反应而非激素副作用。在其他22名患者中的4名，声门图频率指示显示平均频率略有下降，3名患者在人际变化的正常范围内略有上升。没有患者主观上注意到声音有男性化现象。在这项初步研究中，我们在接受测试的23名患者中未发现任何可归因于达那唑雄激素特性的明显嗓音变化。
