与两性霉素B相关的可逆性肝毒性。
Reversible hepatotoxicity related to amphotericin B.
作者信息
Miller M A
出版信息
Can Med Assoc J. 1984 Nov 15;131(10):1245-7.
Abstract
Hepatotoxicity is regarded as a rare side effect of amphotericin B therapy. A patient with acute myelogenous leukemia who had normal liver function was treated with amphotericin B for fungal pneumonia. While he was receiving the drug at high dosages asymptomatic elevation of the levels of alkaline phosphatase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactic dehydrogenase and bilirubin was noted. The levels returned to normal when the drug was discontinued. Rechallenge with a lower dosage prompted a rapid rise in the levels, with subsequent return to normal when the medication was withdrawn.
摘要
肝毒性被视为两性霉素B治疗的一种罕见副作用。一名肝功能正常的急性髓性白血病患者因真菌性肺炎接受两性霉素B治疗。在他接受高剂量药物治疗期间，发现碱性磷酸酶、血清谷草转氨酶、血清谷丙转氨酶、乳酸脱氢酶和胆红素水平无症状升高。停药后这些水平恢复正常。再次以较低剂量用药促使这些水平迅速上升，停药后随后又恢复正常。
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