Nakao Y, Matsuda S, Matsui T, Nakagawa T, Koizumi T, Saida T, Fujita T
Cancer Res. 1984 Dec;44(12 Pt 1):5836-44.
A novel benzophenone derivative, 2-(2-benzoyl-4-chlorophenoxy)-N-methylpropionamide (Ch-13), induced phenotypic differentiation linked to the inhibition of cell proliferation in human thymic acute lymphoblastic leukemia cell line HPB-ALL cells. The Ch-13-induced morphological changes consist of a decrease in cell size, nucleolar disappearance, and an alteration in the chromatin distribution, resembling large or atypical lymphocytes. Treatment with Ch-13 brought about a remarkable reduction in OKT6-, OKT4/Leu3a-, and OKT9-positive cells. At the optimal differentiation-inducing dose (5 X 10(-5)M), Ch-13 inhibited the cell proliferation, de novo DNA synthesis, and specific antibody-induced cell surface antigen capping.
一种新型二苯甲酮衍生物，2-(2-苯甲酰基-4-氯苯氧基)-N-甲基丙酰胺（Ch-13），在人胸腺急性淋巴细胞白血病细胞系HPB-ALL细胞中诱导了与细胞增殖抑制相关的表型分化。Ch-13诱导的形态学变化包括细胞大小减小、核仁消失以及染色质分布改变，类似于大淋巴细胞或非典型淋巴细胞。用Ch-13处理导致OKT6、OKT4/Leu3a和OKT9阳性细胞显著减少。在最佳诱导分化剂量（5×10^(-5)M）下，Ch-13抑制细胞增殖、DNA从头合成以及特异性抗体诱导的细胞表面抗原封帽。
