Nakao Y, Matsui T, Matsuda S, Shiozawa S, Fujita T, Ito Y
Int J Immunopharmacol. 1983;5(5):443-53. doi: 10.1016/0192-0561(83)90021-8.
An ingenol ester, milliamin, induced phenotypic changes in human thymic ALL cell line HPB-ALL. These alterations included morphological changes, increased sRBC-rosetting, the induction of phenotypic changes of differentiation antigens, i.e. a decrease in OKT4-, OKT6-, OKT9-, OKT10- and Leu3a-positive cells and an increase in Leu2a-positive cells, growth inhibition and decreased DNA synthesis. These phenotypic changes were qualitatively and quantitatively similar to those induced by other polyol diterpens with tigliane and daphnane hydrocarbon skeletons such as TPA and mezereine, respectively.
千金二萜醇酯（milliamin）可诱导人胸腺急性淋巴细胞白血病细胞系HPB-ALL发生表型变化。这些改变包括形态变化、增强的绵羊红细胞花环形成、分化抗原表型变化的诱导，即OKT4、OKT6、OKT9、OKT10和Leu3a阳性细胞减少以及Leu2a阳性细胞增加、生长抑制和DNA合成减少。这些表型变化在质量和数量上分别与由其他具有大戟烷和瑞香烷烃骨架的多元醇二萜（如佛波酯和紫堇灵）诱导的变化相似。
