血红蛋白中配体结合与蛋白质亚基缔合之间自由能偶联的顺序。
Order of free energy couplings between ligand binding and protein subunit association in hemoglobin.
作者信息
Weber G
出版信息
Proc Natl Acad Sci U S A. 1984 Nov;81(22):7098-102. doi: 10.1073/pnas.81.22.7098.
Abstract
The number of protein subunits that must be liganded to effect changes in subunit interaction may be characterized by defining an order for the free energy couplings between these two processes. From available data on the chemical equilibrium of stripped hemoglobin A with oxygen, I show that couplings are unequivocally of first order. The two-state model of cooperative binding is shown to be incompatible with the results of this analysis, as the Monod-Wyman-Changeux parameters derived from the same experimental data demand free energy couplings of an order higher than the second.
摘要
必须被配体结合以影响亚基相互作用变化的蛋白质亚基数量，可以通过定义这两个过程之间自由能耦合的顺序来表征。根据脱辅基血红蛋白A与氧气的化学平衡的现有数据，我表明耦合明确是一级的。协同结合的二态模型与该分析结果不兼容，因为从相同实验数据得出的莫诺德 - 怀曼 - 尚热参数要求自由能耦合的阶数高于二阶。
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