[急性婴儿淋巴细胞白血病的免疫和酶学标志物]

[Immunologic and enzymatic markers of acute infantile lymphoblastic leukemias].

作者信息

González M, Tamagnini G, San Miguel J F, Lopes D T, Mateos G, Caballero M D, Ribeiro L, López Borrasca A

出版信息

An Esp Pediatr. 1984 Sep 15;21(3):222-8.

Abstract

Twenty-one childhood acute lymphoblastic leukemias were characterized immunologically by a series of classic markers--EAET rosette and surface and cytoplasm immunoglobulins--, a panel of 14 monoclonal antibodies --OKla 1, OKT3, 4, 6, 8, 9, 10, 11, cALLA, Leu-1, FMC-7, FMC-8 and 3A-1--and by assessment of terminal deoxynucleotidyl transferase enzyme. Patients were distributed in five immunological subgroups: 1) Unclassifiable/null ALL (la +, TdT+, cALLA-), one patient, 2) common ALL (la+, TdT+, cALLA+) 15 patients, 3) pre-B ALL (la+, TdT+, cALLA+, clg+) one patient, 4) B-LL (la+, TdT-, cALLA-, slg+) 3 patients, 5) T-ALL (TdT+, EAET+, la-, cALLA-), one patient, and the clinical, biological, morphological and cytochemical peculiarities characterizing each immunological variant are discussed.

摘要

通过一系列经典标志物——EAET玫瑰花结以及表面和胞质免疫球蛋白、一组14种单克隆抗体——OKla 1、OKT3、4、6、8、9、10、11、cALLA、Leu-1、FMC-7、FMC-8和3A-1——以及对末端脱氧核苷酸转移酶的评估，对21例儿童急性淋巴细胞白血病进行了免疫特征分析。患者被分为五个免疫亚组：1）无法分类/无标记ALL（la +、TdT +、cALLA -），1例患者；2）普通ALL（la +、TdT +、cALLA +），15例患者；3）前B-ALL（la +、TdT +、cALLA +、clg +），1例患者；4）B-LL（la +、TdT -、cALLA -、slg +），3例患者；5）T-ALL（TdT +、EAET +、la -、cALLA -），1例患者，并讨论了每种免疫变异的临床、生物学、形态学和细胞化学特征。