Gazaryan K G, Kuznetsova E D, Eshkind L G, Yazykov A A, Tarantul V Z, Popov L S, Tikhonenko T I, Naroditsky B S
Cell Differ. 1984 Oct;14(4):267-76. doi: 10.1016/0045-6039(84)90015-0.
A simian adenovirus SA7 (C-8) DNA was microinjected into fertilized mouse eggs. Thirty-five mice derived from eggs injected with SA7 DNA were screened for the presence of the adenovirus genome in their liver DNA. Eighteen of these mice contained the virus-specific sequences. SA7 DNA was detected in some tissues, but in all cases, viral sequences were absent from muscle and heart DNA. Viral DNA was inherited by 50-70% of the next generation. One mouse that contained about 1 copy of SA7 DNA per haploid genome has been shown to pass it on to five generations, although the integrated viral DNA sustained a considerable structural change between F1 and F3. RNA analysis in various organs of 12 mice has shown the transcription of SA7 DNA to be very infrequent: only in the kidney of one mouse and in the spleen of another did RNA contain SA7-specific sequences.
将猿猴腺病毒SA7（C - 8）DNA显微注射到受精的小鼠卵中。对35只源自注射了SA7 DNA的卵的小鼠进行筛查，以检测其肝脏DNA中是否存在腺病毒基因组。其中18只小鼠含有病毒特异性序列。在一些组织中检测到了SA7 DNA，但在所有情况下，肌肉和心脏DNA中均未检测到病毒序列。病毒DNA在下一代中的遗传率为50% - 70%。有一只小鼠每个单倍体基因组中约含有1个SA7 DNA拷贝，已证明它能将其传递给五代，尽管整合的病毒DNA在F1和F3之间发生了相当大的结构变化。对12只小鼠的各种器官进行RNA分析表明，SA7 DNA的转录非常罕见：仅在一只小鼠的肾脏和另一只小鼠的脾脏中，RNA含有SA7特异性序列。
