产黄青霉将双标记缬氨酸掺入δ-（L-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸的过程。
Incorporation of double-labelled valine into delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by Penicillium chrysogenum.
作者信息
Adriaens P, Meesschaert B, Vanderhaeghe H, Eyssen H
出版信息
Arch Int Physiol Biochim. 1976 Oct;84(4):767-70. doi: 10.3109/13813457609067051.
PMID:65951
Abstract
The incorporation of valine into the LLD-tripeptide, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine, a precursor of penicillin, was studied by incubating mycelial mats of Penicillium chrysogenum Wis. 49-2105 with double labelled valines. L-valine was incorporated into the LLD-tripeptide without formation of an alpha, beta-didehydrovaline intermediate. Intact D-valine was not incorporated into the LLD-tripeptide.
摘要
通过用双标记缬氨酸培养产黄青霉Wis. 49 - 2105的菌丝垫，研究了缬氨酸掺入青霉素前体LLD - 三肽δ -（L - α - 氨基己二酰）- L - 半胱氨酰 - D - 缬氨酸的情况。L - 缬氨酸掺入LLD - 三肽中，未形成α，β - 脱氢缬氨酸中间体。完整的D - 缬氨酸未掺入LLD - 三肽中。
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