New electron-capture gas-liquid chromatographic method for the determination of mexiletine plasma levels in man.
作者信息
Frydman A, Lafarge J P, Vial F, Rulliere R, Alexandre J M
出版信息
J Chromatogr. 1978 May 1;145(3):401-11. doi: 10.1016/s0378-4347(00)81369-9.
PMID:659526
Abstract
A method for the determination of mexiletine in human plasma by gas-liquid chromatography with electron-capture detection is described. Plasma samples are extracted at pH 12 with dichloromethane after addition of the internal standard, the 2,4-methyl analogue of mexiletine. A derivative is obtained using heptafluorobutyric anhydride; according to gas chromatography-mass spectrometry it is a monoheptafluorobutyryl compound. The minimum detectable amount of mexiletine is 5 pg. Accurate determinations of human plasma levels were performed after oral or intravenous treatment.
摘要
相似文献
1
New electron-capture gas-liquid chromatographic method for the determination of mexiletine plasma levels in man.
J Chromatogr. 1978 May 1;145(3):401-11. doi: 10.1016/s0378-4347(00)81369-9.
2
Simultaneous plasma levels determination of mexiletine and one of its metabolites by electron capture gas-liquid chromatography.
Arzneimittelforschung. 1982;32(6):688-93.
3
Gas-liquid chromatographic determination of mexiletine in human serum with nitrogen sensitive detection.采用氮敏感检测的气相色谱法测定人血清中的美西律。
J Clin Chem Clin Biochem. 1981 Dec;19(12):1189-91. doi: 10.1515/cclm.1981.19.12.1189.
4
Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent.用改良邻苯二甲醛试剂反应后荧光检测法对人血浆中美西律和妥卡尼进行液相色谱测定。
J Chromatogr. 1985 Nov 8;344:221-30. doi: 10.1016/s0378-4347(00)82022-8.
5
Improved gas-liquid chromatographic method for measurement of mexiletine in plasma.
Clin Chem. 1982 Jan;28(1):245-6.
6
Simple gas-liquid chromatographic method for the measurement of mexiletine and lignocaine in blood-plasma or serum.
J Chromatogr. 1979 Feb 1;169:295-301. doi: 10.1016/0021-9673(75)85053-9.
7
Sensitive gas chromatographic method for the estimation of a new antiarrhythmic compound, mexiletine (Ko1173), in biological fluids.
J Chromatogr. 1976 Nov 17;128(1):196-8. doi: 10.1016/s0021-9673(00)84053-4.
8
Mexiletine in plasma by high pressure liquid chromatography.用高压液相色谱法测定血浆中的美西律。
Ther Drug Monit. 1981;3(3):279-86. doi: 10.1097/00007691-198103000-00009.
9
Determination of mexiletine in biological fluids by high-performance liquid chromatography.高效液相色谱法测定生物流体中的美西律
J Chromatogr. 1982 Jun 11;230(1):97-105. doi: 10.1016/s0378-4347(00)81434-6.
10
Improved liquid-chromatographic determination of mexiletine, an antiarrhythmic drug, in plasma.
Clin Chem. 1984 Feb;30(2):319-22.
引用本文的文献
1
Clinical pharmacokinetics of the newer antiarrhythmic agents.新型抗心律失常药物的临床药代动力学
Clin Pharmacokinet. 1984 Sep-Oct;9(5):375-403. doi: 10.2165/00003088-198409050-00001.
Zotero 插件