采用氮敏感检测的气相色谱法测定人血清中的美西律。

Gas-liquid chromatographic determination of mexiletine in human serum with nitrogen sensitive detection.

作者信息

Elfving S M, Svens E H, Leskinen E E

出版信息

J Clin Chem Clin Biochem. 1981 Dec;19(12):1189-91. doi: 10.1515/cclm.1981.19.12.1189.

DOI:10.1515/cclm.1981.19.12.1189

Abstract

A simple and rapid method for the quantitative determination of mexiletine, using gas-liquid chromatography with nitrogen sensitive detection, is described. Only one extraction step is needed, the recovery is between 92-96% and the precision varies between 2.0--5.5%. The lower limit of detection reached 0.5 micro mol/1. During routine handling the method was easy, quick and cheap.

摘要

描述了一种使用带氮敏感检测的气液色谱法定量测定美西律的简单快速方法。仅需一步萃取，回收率在92%至96%之间，精密度在2.0%至5.5%之间。检测下限达到0.5微摩尔/升。在常规操作中，该方法简便、快速且成本低廉。