Nelson J F, Finkelstein M W, Acevedo A, Gonzales G M
Oral Surg Oral Med Oral Pathol. 1984 Nov;58(5):554-60. doi: 10.1016/0030-4220(84)90079-3.
Destructive processes of the midface can occur in a wide variety of diseases. Intrinsic in consideration of these is a cluster of lesions, including Wegener's granulomatosis (WG), idiopathic midline granuloma (IMG), polymorphic reticulosis (PR), and lymphoma. Although there is still confusion as to whether the latter three represent a spectrum of the same malignant process, there is general agreement that WG is a separate entity on the basis of clinical presentation and therapeutic response. It is probable that PR is an emergent lymphoma, with the same prognostic and therapeutic features. Idiopathic midline granuloma is clinically similar to PR and lymphoma, but histologically it appears to be inflammatory in nature with no clearly definable malignant cell type present. At this point in time three diseases are best collectively referred to as midline "nonhealing" granuloma. The cases presented represent the spectrum of this enigmatic process.
面部中部的破坏性病变可发生于多种疾病中。在考虑这些疾病时，本质上是一组病变，包括韦格纳肉芽肿（WG）、特发性中线肉芽肿（IMG）、多形性网状细胞增多症（PR）和淋巴瘤。尽管对于后三种疾病是否代表同一恶性过程的不同阶段仍存在争议，但基于临床表现和治疗反应，人们普遍认为WG是一个独立的疾病实体。PR可能是一种侵袭性淋巴瘤，具有相同的预后和治疗特征。特发性中线肉芽肿在临床上与PR和淋巴瘤相似，但在组织学上它似乎本质上是炎症性的，不存在明确可定义的恶性细胞类型。目前，这三种疾病最好统称为中线“不愈合”肉芽肿。所呈现的病例代表了这一神秘过程的不同阶段。
