Aozasa K, Ohsawa M, Tajima K, Sasaki R, Maeda H, Matsunaga T, Friedmann I
Department of Pathology, Osaka University Medical School, Japan.
Int J Cancer. 1989 Jul 15;44(1):63-6. doi: 10.1002/ijc.2910440112.
Lethal mid-line granuloma (LMG) is a clinical term, and it is histologically composed of Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In the present report, a nation-wide study on LMG in Japan is compared with a study from the UK, to examine differences in frequencies of each disease in Eastern and Western countries. A total of 340 cases of LMG were examined. On the basis of histological and clinical findings, these cases were categorized as 68 WG, 129 PR, 92 ML, 44 chronic inflammation not specified, and 7 other related conditions. The crude frequencies of WG, PR, and ML per 100,000 outpatients of ENT clinics in Japan and England were 4, 8 and 6, respectively and 8, 4 and I, respectively. The predominance of malignant lymphoproliferative diseases to WG in Japan (3.5:1) was in marked contrast to the situation in the UK (1:1.6). A review of the pertinent literature suggests a clustering of malignant lymphoproliferative diseases of the nose among Mongolian ethnic groups.
致死性中线肉芽肿（LMG）是一个临床术语，其组织学上由韦格纳肉芽肿（WG）、多形性网状细胞增生症（PR）和恶性淋巴瘤（ML）组成。WG是一种炎症性疾病，PR和ML被认为代表淋巴网状细胞的肿瘤性增殖。在本报告中，将日本一项关于LMG的全国性研究与英国的一项研究进行比较，以探讨东西方国家每种疾病发病率的差异。共检查了340例LMG病例。根据组织学和临床检查结果，这些病例被分类为68例WG、129例PR、92例ML、44例未明确的慢性炎症以及7例其他相关病症。日本和英国耳鼻喉科门诊每10万名患者中WG、PR和ML的粗发病率分别为4、8和6，以及8、4和1。在日本，恶性淋巴增生性疾病相对于WG的优势（3.5:1）与英国的情况（1:1.6）形成鲜明对比。对相关文献的回顾表明，蒙古人种中鼻部恶性淋巴增生性疾病有聚集现象。
