类二十烷酸对体外细胞增殖的影响：与动脉粥样硬化的相关性。

Eicosanoid effects on cell proliferation in vitro: relevance to atherosclerosis.

作者信息

Smith D L, Willis A L, Mahmud I

出版信息

Prostaglandins Leukot Med. 1984 Oct;16(1):1-10. doi: 10.1016/0262-1746(84)90080-5.

Abstract

Several eicosanoids were tested for ability to inhibit proliferation of cells in culture. In rabbit aortic smooth muscle cells and mouse B16BL6 melanoma cells, order of potency was: 12-HETE greater than PGJ2 greater than PGA1 greater than or equal to PGE1 greater than PGE2 greater than or equal to PGD2 greater than or equal to PGA2. PGB1 was active in smooth muscle cells (greater than PGD2) but not in B16 cells. 5-HETE and Leukotriene B4 were weakly active in smooth muscle cells, and PGB2, PGF2 alpha and TXB2 were inactive in both cells types. In Swiss albino mouse 3T3 fibroblasts, PGJ2 and PGE1 showed much lower relative potency than in the other two cell lines, although the profile was otherwise similar. These findings may be relevant to the anti-atherosclerotic (and perhaps anti-tumor activity) of some eicosanoids.

摘要

测试了几种类花生酸抑制培养细胞增殖的能力。在兔主动脉平滑肌细胞和小鼠B16BL6黑色素瘤细胞中，效力顺序为：12 - HETE大于PGJ2大于PGA1大于或等于PGE1大于PGE2大于或等于PGD2大于或等于PGA2。PGB1在平滑肌细胞中有活性（大于PGD2），但在B16细胞中无活性。5 - HETE和白三烯B4在平滑肌细胞中活性较弱，PGB2、PGF2α和TXB2在两种细胞类型中均无活性。在瑞士白化小鼠3T3成纤维细胞中，PGJ2和PGE1的相对效力比在其他两种细胞系中低得多，尽管其概况在其他方面相似。这些发现可能与某些类花生酸的抗动脉粥样硬化（以及可能的抗肿瘤活性）有关。