Jimerson D C, Cutler N R, Post R M, Rey A, Gold P W, Brown G M, Bunney W E
Psychiatry Res. 1984 Sep;13(1):1-12. doi: 10.1016/0165-1781(84)90113-6.
Increasing evidence implicates altered dopamine function in major affective illness. In the present study, growth hormone responses to the dopamine agonist apomorphine were not different for 14 male depressed patients and 16 healthy male volunteers. Baseline and post-apomorphine prolactin levels were lower for the depressed patients than the control subjects, but the percent decrease following apomorphine was not different for the two groups. Neuroendocrine responses were not significantly altered during chronic treatment with the dopamine agonist piribedil. These neuroendocrine results suggest that decreased baseline prolactin levels in depressed patients do not reflect altered postsynaptic receptor sensitivity in the tuberoinfundibular dopamine system.
越来越多的证据表明多巴胺功能改变与主要情感障碍有关。在本研究中，14名男性抑郁症患者和16名健康男性志愿者对多巴胺激动剂阿扑吗啡的生长激素反应并无差异。抑郁症患者的基线催乳素水平和阿扑吗啡给药后的催乳素水平均低于对照组，但两组阿扑吗啡给药后的催乳素水平下降百分比并无差异。在用多巴胺激动剂匹莫齐特进行长期治疗期间，神经内分泌反应并未发生显著改变。这些神经内分泌结果表明，抑郁症患者基线催乳素水平降低并不反映结节漏斗多巴胺系统中突触后受体敏感性的改变。
