Elphick M, Yang J D, Cowen P J
Oxford University Department of Psychiatry, Littlemore Hospital, Oxford, England.
Arch Gen Psychiatry. 1990 Feb;47(2):135-40. doi: 10.1001/archpsyc.1990.01810140035006.
Neuroendocrine testing was carried out in seven male volunteers before and at the end of a 10-day course of carbamazepine (up to 700 mg daily). After carbamazepine treatment, the prolactin response to intravenous administration of the serotonin precursor tryptophan (5 g) was significantly enhanced, but there was no change in basal plasma tryptophan level or in tryptophan disposition after infusion. The prolactin response to intravenous protirelin (6.25 micrograms) was unaltered. Carbamazepine treatment also produced an increase in the growth hormone response to subcutaneous administration of the dopamine agonist apomorphine hydrochloride (5 micrograms/kg). These data suggest that carbamazepine may alter brain serotonin and dopamine function in humans. Such effects could be involved in the therapeutic properties of carbamazepine in affective disorder.
在7名男性志愿者服用卡马西平（每日剂量高达700毫克）为期10天的疗程之前和结束时，进行了神经内分泌测试。卡马西平治疗后，静脉注射血清素前体色氨酸（5克）引起的催乳素反应显著增强，但基础血浆色氨酸水平或输注后的色氨酸处置情况没有变化。静脉注射促甲状腺素释放激素（6.25微克）引起的催乳素反应未改变。卡马西平治疗还使皮下注射多巴胺激动剂盐酸阿扑吗啡（5微克/千克）后生长激素反应增加。这些数据表明，卡马西平可能改变人类大脑中的血清素和多巴胺功能。这种作用可能与卡马西平在情感障碍中的治疗特性有关。
