Ockelford P A, Powers P J, Hull R D, McLaughlin D, Strasberg Z, Gent M, Hirsh J
Aust N Z J Med. 1984 Oct;14(5):622-5. doi: 10.1111/j.1445-5994.1984.tb05012.x.
Venography remains the standard method for the diagnosis of deep venous thrombosis but it is invasive and frequently causes discomfort. A randomised double-blind study was performed to determine the efficacy of lidocaine in reducing pain and discomfort associated with venography. Sixty patients undergoing ascending venography received 40 mg of lidocaine (2 ml of 2% lidocaine mixed with 50 ml of contrast medium) in one leg and saline in the other. Assessment of pain was by a standard questionnaire administered by an investigator unaware of the sequence of administration of lidocaine or saline placebo. Twenty-four patients reported no difference in pain or discomfort between the two limbs. Of the 36 patients experiencing an overall difference in pain between the two legs, 12 reported more pain in the leg receiving lidocaine and 24 reported more pain in the leg receiving saline (p = 0.023). There were no significant side effects attributable to lidocaine. These results indicate that lidocaine is beneficial in reducing pain and discomfort associated with venography.
静脉造影术仍然是诊断深静脉血栓形成的标准方法，但它具有侵入性，且常常会引起不适。进行了一项随机双盲研究，以确定利多卡因在减轻与静脉造影术相关的疼痛和不适方面的疗效。60例行上行静脉造影术的患者，一条腿接受40毫克利多卡因（2毫升2%利多卡因与50毫升造影剂混合），另一条腿接受生理盐水。由不知道利多卡因或生理盐水安慰剂给药顺序的研究者使用标准问卷对疼痛进行评估。24名患者报告两条腿在疼痛或不适方面没有差异。在两条腿总体疼痛有差异的36名患者中，12名报告接受利多卡因的腿疼痛更严重，24名报告接受生理盐水的腿疼痛更严重（p = 0.023）。没有可归因于利多卡因的明显副作用。这些结果表明，利多卡因有助于减轻与静脉造影术相关的疼痛和不适。
