Eisenberg R L, Mani R L, Hedgcock M W
Radiology. 1978 Apr;127(1):109-11. doi: 10.1148/127.1.109.
In a double-blind study, 28 patients for peripheral angiography received contrast injection both with and without lidocaine. In 22 patients not receiving premedication, the addition of lidocaine to the contrast medium resulted in increased pain in 54.5% of patients and no difference in pain in 41% when compared to contrast alone. In patients premedicated with 5--10 mg Valium intravenously, the addition of lidocaine to the contrast medium resulted in increased pain in half the patients and no difference in the others. The physiologic mechanisms are discussed, and the importance of hyperosmolality of contrast agents in pain production is stressed.
在一项双盲研究中，28名接受外周血管造影的患者在注射造影剂时分别使用了利多卡因和未使用利多卡因。在22名未接受术前用药的患者中，与单独使用造影剂相比，在造影剂中添加利多卡因后，54.5%的患者疼痛加剧，41%的患者疼痛无差异。在静脉注射5-10毫克安定进行术前用药的患者中，在造影剂中添加利多卡因后，一半患者疼痛加剧，另一半患者疼痛无差异。文中讨论了生理机制，并强调了造影剂高渗性在产生疼痛中的重要性。
