银屑病和银屑病关节炎中的人类白细胞抗原（HLA）抗原
HLA antigens in psoriasis and psoriatic arthritis.
作者信息
Woodrow J C, Ilchysyn A
出版信息
J Med Genet. 1985 Dec;22(6):492-5. doi: 10.1136/jmg.22.6.492.
Abstract
HLA phenotypes were determined in 50 patients with psoriasis alone and in 50 patients with psoriasis and psoriatic arthritis. Positive associations were found in both groups with B13, B17, B37, Cw6, and DR7, and in addition with C4A6. Higher relative risks were found in respect to the patients with psoriasis alone compared with those with arthritis, and this suggests the involvement of additional genetic factors predisposing to peripheral arthritis. In patients with psoriasis only, the presence of Cw6 was associated with a significantly earlier age of onset.
摘要
对50例单纯银屑病患者和50例银屑病合并银屑病关节炎患者进行了HLA表型测定。在两组中均发现与B13、B17、B37、Cw6和DR7呈正相关，此外还与C4A6呈正相关。与合并关节炎的患者相比，单纯银屑病患者的相对风险更高，这表明存在其他导致外周关节炎的遗传因素。在仅患有银屑病的患者中，Cw6的存在与发病年龄显著提前有关。
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