Rugg-Gunn A J, Hackett A F, Appleton D R, Jenkins G N, Eastoe J E
Arch Oral Biol. 1984;29(12):983-92. doi: 10.1016/0003-9969(84)90145-6.
The study was conducted in seven schools on children initially aged 11.5 years. They recorded their diet on five occasions, each of three days, and received an annual dental examination, including radiography. Caries increments were low, mostly (58 per cent) in fissure surfaces. Correlations between caries increment and dietary factors were low due to the low caries increments observed and the large error associated with dietary data where analyses attempt to discriminate between individuals. The highest correlation was between caries increment and weight of daily intake of sugars (+0.143, p less than 0.01). Multivariate analyses revealed that this relationship could not be explained by differences in sex, social class, tooth-brushing habits or level of plaque as measured by gingival inflammation. Weight of sugar intake appeared to be more strongly correlated to caries than frequency of intake; concentration of sugars in foods was positively related, and sugars in snacks were more strongly related to caries than total dietary sugars. The 31 children who consumed most sugar (greater than 163 g/day) developed 5.0 DMFS during the 2 years, 0.9 DMFS per year more than the 31 children (3.2 DMFS during 2 years) who had the lowest sugar intake (less than 78 g/day).
该研究在7所学校针对最初年龄为11.5岁的儿童开展。他们在五个不同时间段记录了自己的饮食情况，每个时间段为三天，并接受了包括X光检查在内的年度牙科检查。龋齿增加情况较少，大部分（58%）发生在窝沟表面。由于观察到的龋齿增加量较低，且在分析中试图区分个体时饮食数据存在较大误差，龋齿增加量与饮食因素之间的相关性较低。最高的相关性出现在龋齿增加量与每日糖摄入量之间（+0.143，p小于0.01）。多变量分析显示，这种关系无法用性别、社会阶层、刷牙习惯或通过牙龈炎症测量的牙菌斑水平差异来解释。糖摄入量似乎比摄入频率与龋齿的相关性更强；食物中糖的浓度呈正相关，零食中的糖比总膳食糖与龋齿的关系更强。在两年期间，摄入最多糖（超过163克/天）的31名儿童出现了5.0个恒牙龋失补牙面（DMFS），比摄入最少糖（低于78克/天）的31名儿童（两年期间为3.2个DMFS）每年多0.9个DMFS。
