Civil R H, Warren K S, Mahmoud A A
J Infect Dis. 1978 May;137(5):550-5. doi: 10.1093/infdis/137.5.550.
Intravenous administration of a lyphilized preparation of bacille Calmette-Guérin (BCG-Tice) into mice significantly protected these animals from infection with Schistosoma mansoni. The protective effect depended on the dose of BCG and required the administration of at least 2 X 10(7) viable organisms. The route of administration of BCG was also crucial, as only intravenous inoculation produced significant protection. The BCG-induced resistance was found to last for eight weeks. Significant inflammation of the lungs was observed in mice receiving either viable or heat-killed BCG; however, protection followed only the administration of viable bacilli. Expression of BCG-induced protection was dependent on the presence of significant numbers of viable organisms and may have been associated with pulmonary inflammation at the time of passage of the schistosomula through the lungs.
给小鼠静脉注射冻干的卡介苗（BCG-Tice）制剂可显著保护这些动物免受曼氏血吸虫感染。保护效果取决于卡介苗的剂量，且至少需要注射2×10⁷个活菌体。卡介苗的给药途径也很关键，因为只有静脉接种才能产生显著的保护作用。发现卡介苗诱导的抗性可持续八周。在接受活的或热灭活卡介苗的小鼠中均观察到肺部有明显炎症；然而，只有在注射活菌后才会产生保护作用。卡介苗诱导的保护作用的表达取决于大量活菌体的存在，并且可能与血吸虫幼虫穿过肺部时的肺部炎症有关。
