Fanning M M, Kazura J W
Infect Immun. 1986 May;52(2):534-7. doi: 10.1128/iai.52.2.534-537.1986.
The effect of nonspecific activation of host macrophages by Propionibacterium acnes ("Corynebacterium parvum") or Mycobacterium bovis BCG on Brugia malayi microfilariae was determined by in vitro and in vivo studies. Intraperitoneal injection of C. parvum or BCG stimulated peritoneal exudate cells, which were toxic to microfilariae. Microfilariae were equally susceptible to damage by C57BL/6J or BALB/cJ peritoneal exudate cells. Furthermore, inhibitors of oxidative metabolism and arginine supplementation did not prevent this toxicity, suggesting that the mechanism of microfilarial damage differs from that seen with another multicellular helminth, Schistosoma mansoni. In vivo studies with both BCG and C parvum, however, did not confirm the importance of nonspecific immunity in resistance to B. malayi microfilaremia. Despite the lack of biologic relevance of this phenomenon, in vitro studies may yield important knowledge about the mechanisms of microfilarial damage.
通过体外和体内研究，确定了痤疮丙酸杆菌（“短小棒状杆菌”）或牛分枝杆菌卡介苗对马来布鲁线虫微丝蚴的非特异性激活宿主巨噬细胞的作用。腹腔注射短小棒状杆菌或卡介苗可刺激对微丝蚴有毒性的腹腔渗出细胞。微丝蚴对C57BL/6J或BALB/cJ腹腔渗出细胞的损伤同样敏感。此外，氧化代谢抑制剂和精氨酸补充剂并不能阻止这种毒性，这表明微丝蚴损伤机制与另一种多细胞蠕虫曼氏血吸虫不同。然而，卡介苗和短小棒状杆菌的体内研究并未证实非特异性免疫在抵抗马来布鲁线虫微丝蚴血症中的重要性。尽管这种现象缺乏生物学相关性，但体外研究可能会产生有关微丝蚴损伤机制的重要知识。
