多点连锁分析
Multipoint linkage analysis.
作者信息
Morton N E, MacLean C J, Lew R, Yee S
出版信息
Am J Hum Genet. 1986 Jun;38(6):868-83.
Abstract
A formula is given for the advantage of n-point sampling, which approaches infinity with n. However, 2-point and 3-point analyses extract nearly all the information in such samples and at the same time communicate this information as lods and chi 2, which can be combined with other data by simple addition without reevaluation of the likelihood. When null interference is assumed, map distances and multiple recombination frequencies are inflated, and there is substantial loss of efficiency and of support for the correct order.
摘要
给出了一个关于n点抽样优势的公式，该优势随着n趋近于无穷大。然而，两点和三点分析几乎提取了此类样本中的所有信息，同时将这些信息表示为似然比检验值（lods）和卡方值（chi 2），它们可以通过简单相加与其他数据相结合，而无需重新评估似然性。当假设不存在干扰时，图谱距离和多重重组频率会被夸大，并且在效率以及对正确顺序的支持方面会有大量损失。
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