Stella A, Golin R, Genovesi S, Zanchetti A
J Hypertens Suppl. 1983 Dec;1(2):66-7.
Denervation of one kidney has been shown to induce a prompt decrease in sodium and water excretion from the contralateral kidney. The present study was designed to clarify whether this response is due to suppression of a tonic inhibitory renorenal reflex. Experiments were performed in anaesthetized cats in which the renal nerves of the left kidney were transiently blocked by cooling and the effects of this blockade on either kidney were studied in three different groups of animals. The decrease in sodium and water excretion from the contralateral (right) kidney observed in the sham-operated group (intact dorsal roots) was still present, and substantially unchanged, in the second group of animals in which the ipsilateral (left) dorsal roots from T9 to L4 were cut. In the third group of cats, bilateral dorsal root section entirely abolished the response of the contralateral kidney to renal nerve cooling. These experiments demonstrate that the contralateral decrease in sodium and water excretion is due to the block of afferent renal nerve fibres which project bilaterally to the spinal cord.
一侧肾脏去神经支配已被证明会导致对侧肾脏钠和水排泄迅速减少。本研究旨在阐明这种反应是否是由于紧张性抑制性肾-肾反射的抑制。实验在麻醉猫身上进行，其中左肾的肾神经通过冷却暂时阻断，并在三组不同的动物中研究这种阻断对任一肾脏的影响。在假手术组（完整背根）中观察到的对侧（右）肾脏钠和水排泄减少，在切断T9至L4同侧（左）背根的第二组动物中仍然存在，且基本未变。在第三组猫中，双侧背根切断完全消除了对侧肾脏对肾神经冷却的反应。这些实验表明，对侧钠和水排泄减少是由于双侧投射到脊髓的肾传入神经纤维被阻断。
