Golin R, Stella S A, Genovesi S, Macchi A, Protasoni G, Zanchetti A
J Hypertens Suppl. 1984 Dec;2(3):S465-6.
The reduction in sodium and water excretion observed in the right kidney when the left kidney is subjected to transient denervation, is entirely abolished by bilateral section of the dorsal roots from T9 to L4, whereas section of the left dorsal roots only, at the same spinal level, does not affect the contralateral renal response to left renal nerve cooling. The possibility that the bilateral dorsal roots section abolished the response of the right kidney because the afferent fibres from the left kidney travel in the right dorsal roots was explored in the present study. Experiments were performed in anaesthetized cats in which reversible denervation of the left kidney was done by cooling of left renal nerves (for 10 min) after cutting the right dorsal roots from T9 to L4. Cooling of left renal nerves caused a large increase in sodium and water excretion from the left kidney and a prompt decrease in sodium and water excretion from the right kidney. During the cooling period arterial pressure did not change and glomerular filtration rate slightly increased in the left kidney only. The results obtained in this group of animals were not significantly different from those previously observed in sham-operated cats or in cats with section of left dorsal roots only. As the contralateral antidiuretic and antinatriuretic response to renal denervation survives dorsal root section on either side but is prevented by bilateral section, this demonstrates that the inhibitory renal afferent fibres responsible for this renorenal reflex are distributed bilaterally to spinal dorsal roots.
当左肾受到短暂去神经支配时，右肾钠和水排泄量减少；而当T9至L4的双侧背根被切断后，这种减少完全消失。然而，仅切断同一脊髓水平的左侧背根，并不影响对侧肾脏对左肾神经冷却的反应。本研究探讨了双侧背根切断消除右肾反应的可能性，即左肾的传入纤维是否通过右侧背根传导。实验在麻醉猫身上进行，在切断右侧T9至L4背根后，通过冷却左肾神经（持续10分钟）对左肾进行可逆性去神经支配。冷却左肾神经导致左肾钠和水排泄量大幅增加，右肾钠和水排泄量迅速减少。在冷却期间，动脉血压未发生变化，仅左肾的肾小球滤过率略有增加。该组动物获得的结果与先前在假手术猫或仅切断左侧背根的猫中观察到的结果无显著差异。由于对肾去神经支配的对侧抗利尿和抗钠利尿反应在任何一侧背根切断后均存在，但双侧切断则可阻止，这表明负责这种肾-肾反射的抑制性肾传入纤维双侧分布于脊髓背根。
