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Comparative in vitro and in vivo activity of temocillin (BRL 17421) and ampicillin against Haemophilus influenzae type b.替莫西林（BRL 17421）与氨苄西林对b型流感嗜血杆菌的体外和体内活性比较
Antimicrob Agents Chemother. 1983 Jan;23(1):182-4. doi: 10.1128/AAC.23.1.182.
2
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In vitro and in vivo synergism between amoxicillin and clavulanic acid against ampicillin-resistant Haemophilus influenzae type b.阿莫西林与克拉维酸对耐氨苄西林的b型流感嗜血杆菌的体外及体内协同作用
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引用本文的文献

1
Comparative in vitro activity of temocillin.替莫西林的体外活性比较
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2
Interpretive criteria for temocillin disk diffusion susceptibility testing.替莫西林纸片扩散法药敏试验的解释标准。
Eur J Clin Microbiol. 1985 Feb;4(1):30-3. doi: 10.1007/BF02148656.

本文引用的文献

1
Elaboration of type b capsule by Haemophilus influenzae as a determinant of pathogenicity and impaired killing by trimethoprim-sulfamethoxazole.流感嗜血杆菌b型荚膜的形成作为致病性的决定因素以及甲氧苄啶-磺胺甲恶唑对其杀伤作用的损害
J Clin Invest. 1982 Mar;69(3):658-65. doi: 10.1172/jci110493.
2
Synergistic action of ampicillin and nafcillin against ampicillin-resistant Haemophilus influenzae.氨苄西林和萘夫西林对耐氨苄西林流感嗜血杆菌的协同作用。
Antimicrob Agents Chemother. 1980 Mar;17(3):461-3. doi: 10.1128/AAC.17.3.461.
3
Synergistic action of nafcillin and ampicillin against ampicillin-resistant Haemophilus influenzae type b bacteremia and meningitis in infant rats.萘夫西林和氨苄西林对婴儿大鼠耐氨苄西林的b型流感嗜血杆菌菌血症和脑膜炎的协同作用。
Antimicrob Agents Chemother. 1980 Jul;18(1):122-4. doi: 10.1128/AAC.18.1.122.
4
In vitro activity of BRL 17421 against Haemophilus influenzae, Neisseria gonorrhoeae, and Branhamella catarrhalis.BRL 17421对流感嗜血杆菌、淋病奈瑟菌和卡他布兰汉菌的体外活性。
Antimicrob Agents Chemother. 1982 Jan;21(1):166-7. doi: 10.1128/AAC.21.1.166.
5
Treatment of experimental Haemophilus influenzae type b meningitis with 1-oxa-beta-lactam (LY127935).用1-氧杂-β-内酰胺（LY127935）治疗实验性b型流感嗜血杆菌脑膜炎。
Antimicrob Agents Chemother. 1980 Feb;17(2):258-62. doi: 10.1128/AAC.17.2.258.
6
Susceptibility of Haemophilus influenza to ampicillin as determined by use of a modified, one-minute beta-lactamase test.采用改良的一分钟β-内酰胺酶试验测定流感嗜血杆菌对氨苄西林的敏感性。
Antimicrob Agents Chemother. 1976 Jan;9(1):196-8. doi: 10.1128/AAC.9.1.196.
7
Beta-lactamase effect on ampicillin treatment of Haemophilus influenzae B bacteremia and meningitis in infant rats.β-内酰胺酶对氨苄西林治疗幼鼠B型流感嗜血杆菌菌血症和脑膜炎的影响。
Antimicrob Agents Chemother. 1977 Oct;12(4):461-4. doi: 10.1128/AAC.12.4.461.

替莫西林（BRL 17421）与氨苄西林对b型流感嗜血杆菌的体外和体内活性比较

Comparative in vitro and in vivo activity of temocillin (BRL 17421) and ampicillin against Haemophilus influenzae type b.

作者信息

Yogev R, Glogowski W, Connor E

出版信息

Antimicrob Agents Chemother. 1983 Jan;23(1):182-4. doi: 10.1128/AAC.23.1.182.

DOI:10.1128/AAC.23.1.182
PMID:6600909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC184641/
Abstract

A total of 42 strains of Haemophilus influenzae type b isolated from pediatric patients were sensitive in vitro to temocillin (90% minimal inhibitory concentration = 0.25 microgram/ml). No difference in mean minimal inhibitory concentration between beta-lactamase producer (0.25 microgram/ml) and nonproducer (0.23 microgram/ml) strains was found. Various dosages of ampicillin or temocillin for the treatment of infant rats with ampicillin-resistant H. influenzae bacteremia and meningitis yielded no difference in cure rates. These results suggest that temocillin may not be as effective as other new cephalosporins for the treatment of H. influenzae type b infections.

摘要

从儿科患者中分离出的42株b型流感嗜血杆菌在体外对替莫西林敏感（90%的最低抑菌浓度=0.25微克/毫升）。产β-内酰胺酶菌株（0.25微克/毫升）和不产β-内酰胺酶菌株（0.23微克/毫升）之间的平均最低抑菌浓度没有差异。用不同剂量的氨苄西林或替莫西林治疗患有耐氨苄西林b型流感嗜血杆菌菌血症和脑膜炎的幼鼠，治愈率没有差异。这些结果表明，在治疗b型流感嗜血杆菌感染方面，替莫西林可能不如其他新型头孢菌素有效。