替莫西林（BRL 17421）与氨苄西林对b型流感嗜血杆菌的体外和体内活性比较
Comparative in vitro and in vivo activity of temocillin (BRL 17421) and ampicillin against Haemophilus influenzae type b.
作者信息
Yogev R, Glogowski W, Connor E
出版信息
Antimicrob Agents Chemother. 1983 Jan;23(1):182-4. doi: 10.1128/AAC.23.1.182.
Abstract
A total of 42 strains of Haemophilus influenzae type b isolated from pediatric patients were sensitive in vitro to temocillin (90% minimal inhibitory concentration = 0.25 microgram/ml). No difference in mean minimal inhibitory concentration between beta-lactamase producer (0.25 microgram/ml) and nonproducer (0.23 microgram/ml) strains was found. Various dosages of ampicillin or temocillin for the treatment of infant rats with ampicillin-resistant H. influenzae bacteremia and meningitis yielded no difference in cure rates. These results suggest that temocillin may not be as effective as other new cephalosporins for the treatment of H. influenzae type b infections.
摘要
从儿科患者中分离出的42株b型流感嗜血杆菌在体外对替莫西林敏感（90%的最低抑菌浓度=0.25微克/毫升）。产β-内酰胺酶菌株（0.25微克/毫升）和不产β-内酰胺酶菌株（0.23微克/毫升）之间的平均最低抑菌浓度没有差异。用不同剂量的氨苄西林或替莫西林治疗患有耐氨苄西林b型流感嗜血杆菌菌血症和脑膜炎的幼鼠，治愈率没有差异。这些结果表明，在治疗b型流感嗜血杆菌感染方面，替莫西林可能不如其他新型头孢菌素有效。
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