β-内酰胺酶对氨苄西林治疗幼鼠B型流感嗜血杆菌菌血症和脑膜炎的影响。
Beta-lactamase effect on ampicillin treatment of Haemophilus influenzae B bacteremia and meningitis in infant rats.
作者信息
Moxon E R, Medeiros A A, O'Brien T F
出版信息
Antimicrob Agents Chemother. 1977 Oct;12(4):461-4. doi: 10.1128/AAC.12.4.461.
Abstract
Intraperitoneal injections of 250 mg of ampicillin per kg every 6 h for 30 h sterilized the blood and cerebrospinal fluid of infant rats infected with either a beta-lactamase-containing strain of Haemophilus influenzae type b or a strain lacking the enzyme. However, a single injection of 100 mg/kg sterilized the blood and cerebrospinal fluid of significantly fewer of those rats infected with the beta-lactamase-producing strain. The results suggest that resistance of beta-lactamase-containing strains of H. influenzae in vivo may be inoculum dependent, as demonstrated previously in vitro. The infant rat model appears suited for the quantitative delineation of the effect of beta-lactamase on the treatment of H. influenzae bacteremia and meningitis with beta-lactamase antibiotics.
摘要
每6小时给幼鼠腹腔注射250毫克/千克氨苄青霉素，持续30小时，可使感染含β-内酰胺酶的b型流感嗜血杆菌菌株或不含该酶菌株的幼鼠的血液和脑脊液无菌。然而，单次注射100毫克/千克只能使感染产β-内酰胺酶菌株的幼鼠中显著更少比例的血液和脑脊液无菌。结果表明，体内含β-内酰胺酶的流感嗜血杆菌菌株的耐药性可能如先前体外实验所示，与接种量有关。幼鼠模型似乎适合定量描述β-内酰胺酶对用β-内酰胺酶抗生素治疗流感嗜血杆菌菌血症和脑膜炎的影响。
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