Tønnesen B, Rolstad B
Scand J Immunol. 1983 Apr;17(4):303-12. doi: 10.1111/j.1365-3083.1983.tb00794.x.
The distribution of allogeneic and syngeneic thoracic duct lymphocytes was studied over 24 h in normal and T-cell-deficient animals (thymectomized, irradiated rats, 'B rats', or congenitally athymic nude rats). Initial migration from blood was no less for allogenic than for syngeneic cells. After 24 h, however, a marked deficit of radioactively labelled allogeneic cells as compared with syngeneic cells was found in the lymphoid tissue, whereas the allogeneic isotope was recovered in a relatively greater amount in liver, kidneys, and cell-free plasma and lymph. Most of the allogeneic cells are evidently destroyed within the first 24 h and their isotope released into body fluids. Our studies also revealed this process to be even more evident in T-cell-depleted environments. Autoradiographic studies of recipient nude rat spleens showed that allogeneic cells were not found in the great number seen in syngeneic transfers, but a high grain density in the periarteriolar lymphocyte sheath area could be observed. Granula seemed to be predominantly located over large nonlymphoid cells. The elimination of allogeneic lymphocytes is therefore governed by mechanisms independent of an intact thymus and may be due to a cell population or factor more active in nude animals than in their non-nude littermates.
在正常和T细胞缺陷动物（胸腺切除、经辐射的大鼠，即“B大鼠”，或先天性无胸腺裸鼠）中，对同种异体和同基因胸导管淋巴细胞的分布进行了24小时的研究。从血液中的初始迁移，同种异体细胞并不少于同基因细胞。然而，24小时后，在淋巴组织中发现，与同基因细胞相比，放射性标记的同种异体细胞明显减少，而同种异体同位素在肝脏、肾脏以及无细胞血浆和淋巴中回收的量相对较多。大多数同种异体细胞显然在最初的24小时内被破坏，其同位素释放到体液中。我们的研究还表明，在T细胞耗竭的环境中，这一过程更为明显。对受体裸鼠脾脏的放射自显影研究表明，在同基因移植中所见的大量同种异体细胞未被发现，但在动脉周围淋巴细胞鞘区域可观察到高颗粒密度。颗粒似乎主要位于大型非淋巴细胞上。因此，同种异体淋巴细胞的清除受独立于完整胸腺的机制控制，可能是由于裸鼠体内比其非裸同窝仔鼠中更活跃的细胞群体或因子所致。
