Kirkeby O J, Larsen T B, Lereim P
Institute for Surgical Research, University of Oslo, Norway.
Acta Orthop Scand. 1991 Oct;62(5):459-62. doi: 10.3109/17453679108996644.
Revascularization, new bone formation, and resorption of fresh syngeneic and allogeneic cancellous bone that were transplanted to an intramuscular pouch have been studied in athymic and normal rats. Revascularization was evaluated with radioactive microspheres; formation of new bone was assessed with 85Sr incorporation; and resorption was measured by the graft weight reduction. Animals were killed 2, 6, or 12 weeks after transplantation. The circulation and bone formation in allogeneic grafts were greatly impaired in normal rats as compared with the athymic group and the syngeneic grafts. The allografts in normal rats had a smaller weight reduction than the allografts in athymic rats, suggesting impaired resorption. We conclude that the T-lymphocyte system is at least partly responsible for the difference between syngeneic and allogeneic bone grafts, and that the thymus-dependent primary rejection mechanism probably is important for the vitality of allogeneic bone grafts.
已在无胸腺大鼠和正常大鼠中研究了移植至肌袋的新鲜同基因和异基因松质骨的血管再生、新骨形成及吸收情况。采用放射性微球评估血管再生；通过掺入85Sr评估新骨形成；通过移植物重量减轻测量吸收情况。在移植后2周、6周或12周处死动物。与无胸腺组和同基因移植物相比，正常大鼠中异基因移植物的循环和骨形成受到极大损害。正常大鼠中的异基因移植物重量减轻比无胸腺大鼠中的异基因移植物小，提示吸收受损。我们得出结论，T淋巴细胞系统至少部分导致了同基因和异基因骨移植物之间的差异，且胸腺依赖性初次排斥机制可能对异基因骨移植物的活力很重要。
