亚最小抑菌浓度的氨基糖苷类药物对金黄色葡萄球菌青霉素酶产生的影响。
Effects of subminimal inhibitory concentrations of aminoglycosides on the penicillinase production of Staphylococcus aureus.
作者信息
Stessman J, Michel J
出版信息
Chemotherapy. 1983;29(2):116-20. doi: 10.1159/000238184.
The effects of subminimal inhibitory concentrations of kanamycin, amikacin and gentamicin on the production of penicillinase by Staphylococcus aureus were tested on 12 penicillin-resistant strains. Of the 36 experiments performed, 16 (44%) displayed an increase and 9 (25%) produced a decrease in the penicillinase activity of the strains. These effects were observed at concentrations ranging from 1:2 to 1:2,048 of the respective minimal inhibitory concentration, irrespective of the susceptibility of the strain to the aminoglycoside drug.
对12株耐青霉素的金黄色葡萄球菌菌株，测试了低于最低抑菌浓度的卡那霉素、阿米卡星和庆大霉素对青霉素酶产生的影响。在进行的36次实验中，16次（44%）显示菌株的青霉素酶活性增加，9次（25%）显示活性降低。在各自最低抑菌浓度的1:2至1:2048范围内观察到这些效应，与菌株对氨基糖苷类药物的敏感性无关。
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