次最小抑菌浓度的红霉素、克林霉素和普那霉素对金黄色葡萄球菌青霉素酶产生的影响。
Effects of subminimal inhibitory concentrations of Erythromycin, Clindamycin, and Pristinamycin on the penicillinase production of Staphlyococcus aureus.
作者信息
Michel J, Stessman P, Stessman J
出版信息
Antimicrob Agents Chemother. 1980 Jan;17(1):13-5. doi: 10.1128/AAC.17.1.13.
Abstract
The influence of subminimal inhibitory concentrations of erythromycin, clindamycin, and pristinamycin on the penicillinase production of Staphylococcus aureus was tested in 12 strains. Of the 36 experiments performed, 16 (44%) showed a lack of influence, 10 (28%) displayed an increase, and 10 revealed a decrease in penicillinase activity. The maximal effect produced was generally induced by concentrations ranging from 1/4 to 1/32 the minimal inhibitory concentration, irrespective of the susceptibility of the strain to the drug. In spite of the fact that the drugs are closely related, they sometimes produced opposite effects on the same strain.
摘要
在12株金黄色葡萄球菌中测试了低于最低抑菌浓度的红霉素、克林霉素和 pristinamycin 对青霉素酶产生的影响。在进行的36次实验中，16次（44%）显示无影响，10次（28%）显示增加，10次显示青霉素酶活性降低。产生的最大效应通常由最低抑菌浓度的1/4至1/32范围内的浓度诱导，与菌株对药物的敏感性无关。尽管这些药物密切相关，但它们有时对同一菌株产生相反的作用。
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