Miller T, Phillips S
Antimicrob Agents Chemother. 1983 Mar;23(3):422-8. doi: 10.1128/AAC.23.3.422.
The belief that a favorable physiological milieu in the urinary tract may augment the effectiveness of antimicrobial agents used to treat urinary tract infections was examined by using an experimental model of Escherichia coli-induced renal infection in rats. The effect of manipulating urinary pH and flow on the antimicrobial activities of gentamicin, carbenicillin, ampicillin, nitrofurantoin and co-trimoxazole was assessed. In addition, a potential synergistic effect of the sequential administration of gentamicin and cephalothin in the eradication of renal infection was investigated. Although significant physiological alterations were achieved, these did not affect the efficacy of the antimicrobial agents studied, and therapeutic failures were common.
通过使用大鼠大肠杆菌诱导的肾脏感染实验模型，研究了尿路中有利的生理环境可能增强用于治疗尿路感染的抗菌药物疗效这一观点。评估了调节尿液pH值和流量对庆大霉素、羧苄青霉素、氨苄青霉素、呋喃妥因和复方新诺明抗菌活性的影响。此外，还研究了庆大霉素和头孢噻吩序贯给药在根除肾脏感染方面的潜在协同作用。尽管实现了显著的生理改变，但这些并未影响所研究抗菌药物的疗效，治疗失败很常见。
