瘢痕形成作为影响肾盂肾炎中肾脏微生物清除的一个因素。
Scarring as a factor affecting the eradication of microorganisms from the kidney in pyelonephritis.
作者信息
Miller T
出版信息
Antimicrob Agents Chemother. 1983 Mar;23(3):500-2. doi: 10.1128/AAC.23.3.500.
Abstract
The inability of antimicrobial agents to penetrate scarred renal tissue may explain some therapeutic failures. We examined the effect of scarring on antimicrobial therapy by using a unique animal model in which both kidneys were infected to the same degree but only one kidney was scarred. Scar formation could not explain the failure of ampicillin or nitrofurantoin to eradicate renal infection, but co-trimoxazole was less effective in the presence of tissue damage and scar formation than in their absence.
摘要
抗菌药物无法穿透瘢痕化的肾组织可能是一些治疗失败的原因。我们通过使用一种独特的动物模型来研究瘢痕形成对抗菌治疗的影响，在该模型中，双侧肾脏感染程度相同，但只有一侧肾脏形成瘢痕。瘢痕形成并不能解释氨苄西林或呋喃妥因根除肾脏感染失败的原因，但在存在组织损伤和瘢痕形成的情况下，复方新诺明的疗效低于不存在这些情况时。
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