Moran T H, Schwartz G J, Blass E M
Brain Res. 1983 Apr;283(2-3):197-204. doi: 10.1016/0165-3806(83)90176-1.
Rat pups, 3, 6, 10 and 15 days old, received 500 ms pulse trains of electrical stimulation to the medial forebrain bundle (MFB) at the level of the lateral hypothalamus in the presence of milk. Pups receiving stimulation ingested more milk than littermate controls during a 30-min test at 3, 6 and 10 days of age. Day 15 pups did not. Stimulated pups through day 10 were more active than controls and exhibited the organized behaviors of mouthing, licking, gaping, stretch and even lordosis. Stimulated pups that ingested more milk continued to show increased activity through the 30-min test period, while the activity of control pups demonstrated a satiety effect. Milk augmented the activation of stimulation alone, increasing the incidence of all behaviors in 3-day-old pups and channelled the behavior of older pups into ingestion. Behaviors incompatible with ingestion such as lordosis were selectively inhibited by the presence of milk in stimulated day 10 pups. These results suggest a high degree of behavioral organization in neonatal rats than can be elicited by MFB stimulation and that becomes more goal-directed with age.
3日龄、6日龄、10日龄和15日龄的幼鼠在有乳汁的情况下，接受对下丘脑外侧水平的内侧前脑束（MFB）进行500毫秒的电刺激脉冲串。在3日龄、6日龄和10日龄的30分钟测试期间，接受刺激的幼鼠比同窝对照幼鼠摄入更多的乳汁。15日龄的幼鼠则不然。到10日龄为止，接受刺激的幼鼠比对照幼鼠更活跃，并且表现出如张口、舔舐、打哈欠、伸展甚至脊柱前凸等有组织的行为。摄入更多乳汁的受刺激幼鼠在30分钟的测试期内持续表现出活动增加，而对照幼鼠的活动则表现出饱腹感效应。乳汁增强了单独刺激的激活作用，增加了3日龄幼鼠所有行为的发生率，并将大龄幼鼠的行为导向摄食。在受刺激的10日龄幼鼠中，乳汁的存在选择性地抑制了与摄食不相容的行为，如脊柱前凸。这些结果表明，新生大鼠存在高度的行为组织，可由MFB刺激引发，并且随着年龄增长变得更具目标导向性。
