Moran T H, Schwartz G J, Blass E M
J Neurosci. 1983 Jan;3(1):10-9. doi: 10.1523/JNEUROSCI.03-01-00010.1983.
Brief trains of electrical stimulation (500 msec) were administered to 3-, 6-, 10-, and 15-day-old rat pups through electrodes directed at the medical forebrain bundle (MFB) at the level of the lateral hypothalamus. Stimulation was given at three different frequencies: once per 30 sec, once per 20 sec, and once per 10 sec. Pups 10 days of age and younger became behaviorally activated by stimulation and reliably emitted a series of behavioral responses including mouthing, licking, pawing, gaping, probing, and stretch and lordosis responses. Behavior increased with increasing frequency of stimulation and became more organized with age. Sequences of organized behavior patterns are elicited by MFB stimulation which in their culmination take on the characteristics of motivational responses. Fifteen-day-old pups did not respond to these stimulation parameters. These findings indicate that the components of motivational systems are present and can be elicited at an early age. As development progresses, responses become more organized until stimulation parameters effective in rats 3 to 10 days of age become ineffective in activating behavior in day 15 pups.
通过位于下丘脑外侧水平的电极，对3日龄、6日龄、10日龄和15日龄的幼鼠进行短暂的电刺激（500毫秒），刺激部位为内侧前脑束（MFB）。以三种不同频率进行刺激：每30秒一次、每20秒一次和每10秒一次。10日龄及更小的幼鼠受到刺激后行为被激活，并可靠地发出一系列行为反应，包括张口、舔舐、抓挠、打哈欠、探索以及伸展和脊柱前凸反应。行为随着刺激频率的增加而增加，并且随着年龄增长变得更加有组织性。MFB刺激引发有组织的行为模式序列，这些序列最终呈现出动机反应的特征。15日龄的幼鼠对这些刺激参数没有反应。这些发现表明，动机系统的组成部分在早期就已存在并且可以被激发。随着发育的进行，反应变得更加有组织，直到对3至10日龄大鼠有效的刺激参数在激活15日龄幼鼠的行为时变得无效。
