Neubauer B, Gundersen H J
J Neurol Neurosurg Psychiatry. 1978 May;41(5):417-9. doi: 10.1136/jnnp.41.5.417.
A simple method requiring only an ordinary ECG apparatus and a ruler has shown a hitherto unknown abnormality of the autonomic nervous sysyem in patients with multiple sclerosis. The main findings were that both long-term and short-term variations in heart rate were reduced in patients wirh multiple sclerosis. The reduction was comparable with that observed in other patients with autonomic abnormalities-for example, long-term diabetics-but in addition patients with multiple sclerosis presented unexpected large shifts in pulse rate levels, lasting from a few to 10 or 20 beats.
一种仅需普通心电图设备和一把尺子的简单方法,已显示出多发性硬化症患者存在一种迄今未知的自主神经系统异常。主要发现是,多发性硬化症患者的心率长期和短期变异性均降低。这种降低程度与在其他自主神经异常患者中观察到的情况相当,例如长期糖尿病患者,但此外,多发性硬化症患者的脉搏率水平还出现了意想不到的大幅波动,持续数下至10或20下心跳。