Andersen E B, Nordenbo A M
Department of Neurology, Hvidovre University Hospital, Copenhagen, Denmark.
Clin Auton Res. 1997 Feb;7(1):13-6. doi: 10.1007/BF02267621.
Centrally and locally mediated sympathetic vasoconstrictor responses in skeletal muscle and subcutaneous tissue were studied in six patients with definite multiple sclerosis and severely affected thermoregulatory sweating. The purpose of the study was to evaluate vasomotor function in patients with pronounced thermoregulatory dysfunction and to differentiate between locally and centrally elicited vasomotor reflexes in two different tissues. The method used, the 133-Xenon washout technique, makes such a distinction possible. In spite of the severe sweating disturbances, we found centrally and locally mediated sympathetic vasomotor reflexes to be preserved in skeletal muscle and subcutaneous tissue. The results support the view that sudomotor and vasomotor functions are independently controlled. Previously described differences in sympathetic vasoconstrictor responses in skeletal muscle and subcutaneous tissue in several other neurological disorders are not present in patients with multiple sclerosis, based on our results.
对6例明确诊断为多发性硬化症且体温调节性出汗严重受损的患者，研究了骨骼肌和皮下组织中由中枢和局部介导的交感缩血管反应。本研究的目的是评估体温调节功能明显障碍患者的血管运动功能，并区分两种不同组织中由局部和中枢引发的血管运动反射。所采用的133-氙清除技术使得这种区分成为可能。尽管出汗障碍严重，但我们发现骨骼肌和皮下组织中由中枢和局部介导的交感血管运动反射仍得以保留。这些结果支持了发汗运动和血管运动功能受独立控制的观点。根据我们的结果，在其他几种神经系统疾病中先前描述的骨骼肌和皮下组织交感缩血管反应的差异在多发性硬化症患者中并不存在。
