Terrence C, Alberts M
J Neurol Neurosurg Psychiatry. 1978 May;41(5):463-5. doi: 10.1136/jnnp.41.5.463.
Ambulant patients with recently diagnosed generalised or psychomotor seizure disorders or both were randomly assigned to two dosage regimens of phenytoin. Drug compliance was evaluated with subsequent blood phenytoin levels four to eight weeks after initial enrollment into the study. Although the two groups had similar mg-kg daily dosages of phenytoin, the mean blood levels were statistically different between the two groups, favoring the simplified dosage regimen. Once or twice a day dosage regimens of phenytoin had a beneficial effect on drug compliance when compared to more frequent regimens as measured by phenytoin blood levels.
近期诊断为全身性或精神运动性癫痫发作障碍或两者皆有的门诊患者被随机分配到苯妥英钠的两种给药方案。在最初纳入研究四至八周后，通过后续的苯妥英钠血药浓度评估药物依从性。尽管两组苯妥英钠的每日毫克/千克剂量相似，但两组之间的平均血药浓度在统计学上存在差异，简化给药方案更具优势。与通过苯妥英钠血药浓度衡量的更频繁给药方案相比，苯妥英钠每日一次或两次的给药方案对药物依从性有有益影响。
