癫痫患者血浆苯妥英水平的分布情况。
The distribution of plasma phenytoin levels in epileptic patients.
作者信息
Lascelles P T, Kocen R S, Reynolds E H
出版信息
J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):501-5. doi: 10.1136/jnnp.33.4.501.
Abstract
Plasma phenytoin levels were estimated in 111 adult epileptic patients. A wide scatter of values was found, with over half outside the therapeutic limits of 10 to 20 μg/ml. Phenytoin tolerance tests carried out in five patients revealed a possible failure to metabolize the drug adequately in three of them. Factors affecting the plasma phenytoin level are discussed. The importance of this assay is seen in view of the number of patients potentially at risk from toxic blood levels in the absence of accepted clinical manifestations of acute or subacute intoxication.
摘要
对111名成年癫痫患者的血浆苯妥英水平进行了评估。发现数值分布广泛，超过一半超出了10至20μg/ml的治疗范围。对5名患者进行的苯妥英耐受性测试显示，其中3人可能存在药物代谢不足的情况。讨论了影响血浆苯妥英水平的因素。鉴于在没有急性或亚急性中毒公认临床表现的情况下，有潜在中毒血药浓度风险的患者数量，该检测的重要性可见一斑。
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