Friede R L
J Neuropathol Exp Neurol. 1978 May;37(3):300-13. doi: 10.1097/00005072-197805000-00007.
A tumor of highly unusual composition was found in the lower medulla oblongata of a 3 year, 9 months old girl. Light microscopy of the lesion showed an intimate intermingling of astroglial processes with collagen fibers, both projecting congruent to the pattern of preexisting fiber tracts. Electronmicroscopy disclosed a mosaic formed by the intimate apposition of collagen bundles, of glial processes filled with glial fibrils, and of scattered myelinated fibers, all abutting upon each other, often without intervening basement membranes. This well differentiated mass within the medulla adjoined a dedifferentiated endophytic extension of the tumor into the fourth ventricle which had seeded into the cerebellar cortex and the cauda equina. The dedifferentiated portion of the neoplasm also displayed intimate apposition of collagenous and glial elements. The tumor was tentatively identified as a gliofibroma or a desmo-plastic glioma.
在一名3岁9个月大女童的延髓下部发现了一个成分极为特殊的肿瘤。病变的光镜检查显示星形胶质细胞突起与胶原纤维紧密交织，二者均与原有纤维束的走行方向一致。电镜检查发现，胶原束、充满胶质原纤维的胶质细胞突起以及散在的有髓纤维紧密相邻，形成一种镶嵌结构，它们常常彼此相邻，中间没有基底膜。延髓内这个分化良好的肿块毗邻肿瘤向第四脑室的去分化内生性延伸部分，该延伸部分已播散至小脑皮质和马尾。肿瘤的去分化部分也显示出胶原成分与胶质成分紧密相邻。该肿瘤初步诊断为神经胶质纤维瘤或促结缔组织增生性胶质瘤。
