半抗原反应性诱导性T细胞。I. 两类半抗原特异性诱导性细胞的定义。
Hapten-reactive inducer T cells. I. Definition of two classes of hapten-specific inducer cells.
作者信息
Clayberger C, Dekruyff R H, Aisenberg J, Cantor H
出版信息
J Exp Med. 1983 Jun 1;157(6):1906-19. doi: 10.1084/jem.157.6.1906.
Abstract
Hapten-reactive inducer T cell clones can be divided into two groups based on their activation specificity. The first and largest group is conjugate specific. These clones are activated only by hapten coupled to the same carrier protein used for in vitro selection. The second group, which is quite rare, is hapten specific. Clones of this type are activated by hapten coupled to all foreign and autologus proteins tested. Both types of clones corecognize soluble antigen in association with products of the I-A locus. The hapten-specific cells were used to analyze the molecular basis of I-A vs. I-E gene control. The physiologic significance of hapten- and carrier-specific inducer T cells in the response to foreign antigens and autoantigens is discussed.
摘要
半抗原反应性诱导性T细胞克隆可根据其激活特异性分为两组。第一组也是最大的一组是共轭特异性的。这些克隆仅被与用于体外选择的相同载体蛋白偶联的半抗原激活。第二组非常罕见，是半抗原特异性的。这类克隆被与所有测试的外源和自身蛋白偶联的半抗原激活。两种类型的克隆都与I-A基因座的产物共同识别可溶性抗原。半抗原特异性细胞被用于分析I-A与I-E基因控制的分子基础。讨论了半抗原特异性和载体特异性诱导性T细胞在对外源抗原和自身抗原反应中的生理意义。
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