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半抗原反应性诱导T细胞。II. T细胞受体的分泌形式诱导抗体产生的证据。

Hapten reactive inducer T cells. II. Evidence that a secreted form of the T cell receptor induces antibody production.

作者信息

Dekruyff R H, Clayberger C, Cantor H

出版信息

J Exp Med. 1983 Dec 1;158(6):1881-94. doi: 10.1084/jem.158.6.1881.

DOI:10.1084/jem.158.6.1881
PMID:6196433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187175/
Abstract

The biologic activity of molecules synthesized and secreted by hapten-specific inducer T cells was examined. After activation, a single inducer clone secretes both antigen-specific inducer peptides as well as nonspecific factors. The nonspecific factors augment the in vitro response of B cells to sheep erythrocytes (SRBC) and Type 2 T-independent antigens. The antigen-specific molecules (ABM) induce plaque-forming cell (PFC) responses in cultures containing ABM, B cells, and antigen that links the epitope recognized by ABM with the B cell epitope. Induction of B cells by ABM is limited to B cells expressing the same I-A allele as the source of the ABM and this reflects binding by ABM to I-A products on B lymphocytes. The data reported here strongly support the view that inducer cells can activate at least some B cells by secretion of a modified form of the T cell surface receptor.

摘要

对半抗原特异性诱导性T细胞合成和分泌的分子的生物学活性进行了检测。激活后，单个诱导性克隆既分泌抗原特异性诱导肽，也分泌非特异性因子。这些非特异性因子增强了B细胞对绵羊红细胞（SRBC）和2型非T细胞依赖性抗原的体外反应。抗原特异性分子（ABM）在含有ABM、B细胞以及将ABM识别的表位与B细胞表位相连的抗原的培养物中诱导形成空斑形成细胞（PFC）反应。ABM对B细胞的诱导作用仅限于表达与ABM来源相同I-A等位基因的B细胞，这反映了ABM与B淋巴细胞上的I-A产物的结合。此处报道的数据有力地支持了这样一种观点，即诱导细胞可通过分泌修饰形式的T细胞表面受体激活至少一些B细胞。

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本文引用的文献

1
Use of the T lymphocyte regulated type 2 antigens for the analysis of responsiveness of Lyb5+ and Lyb5- B lymphocytes to T lymphocyte derived factors.利用T淋巴细胞调节的2型抗原分析Lyb5 +和Lyb5 - B淋巴细胞对T淋巴细胞衍生因子的反应性。
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T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.T细胞衍生的B细胞分化因子。对小鼠B细胞同种型转换的影响。
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3
Role of the major histocompatibility complex in T cell activation of B cell subpopulations. Major histocompatibility complex-restricted and -unrestricted B cell responses are mediated by distinct B cell subpopulations.主要组织相容性复合体在B细胞亚群T细胞激活中的作用。主要组织相容性复合体限制和非限制的B细胞反应由不同的B细胞亚群介导。
J Exp Med. 1981 Oct 1;154(4):1100-15. doi: 10.1084/jem.154.4.1100.
4
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。VII. 独特型特异性对空斑形成细胞应答的抑制作用
J Exp Med. 1981 Mar 1;153(3):640-52. doi: 10.1084/jem.153.3.640.
5
B cell helper factors. II. Synergy among three helper factors in the response of T cell- and macrophage-depleted B cells.B细胞辅助因子。II. 三种辅助因子在T细胞和巨噬细胞缺陷的B细胞应答中的协同作用。
J Immunol. 1982 Oct;129(4):1398-402.
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Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen.经刺激的T细胞系的培养上清液具有辅助活性，该活性在B细胞对抗原的应答中与白细胞介素2协同发挥作用。
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H-2-restricted antigen binding by a hybridoma clone that produces antigen-specific helper factor.产生抗原特异性辅助因子的杂交瘤克隆的H-2限制性抗原结合
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