Hackbarth H, Büttner D, Jarck D, Pothmann M, Messow C, Gärtner K
Ren Physiol. 1983;6(2):63-71. doi: 10.1159/000172882.
The glomerular distribution in the renal cortex of the Munich Wistar Frömter (MWF) rat, a substrain of the Munich Wistar rat selected for superficial glomeruli, was compared to that of a control strain (LEW/Ztm) between 10 and 150 days of age. While there were no significant differences in body growth, kidney weight, or growth of the renal cortex in these two strains, the average diameter of Bowman's capsule and of the glomerular tuft was significantly larger (about 12%) in rats of the MWF strain which were older than 60 days. In histological sections of kidneys of MWF rats in all age groups, many glomeruli in direct contact with the renal capsule were found; thus, this developmental step must have taken place before 10 days of age. The appearance of superficial glomeruli was due to a shift of glomeruli to a position just under the renal surface, the subcapsular zone or 'cortex corticis', which is normally free of glomeruli. For the rest of the renal cortex there were only slight differences in glomerular density and in total number of glomeruli per section between these two strains. These results lead us to suppose that superficial glomeruli belong to a special nephron type; thus, these glomeruli are not enveloped by parts of the proximal tubule.
将慕尼黑威斯塔大鼠的一个亚系——慕尼黑威斯塔弗勒姆特（MWF）大鼠（因其浅表性肾小球而被选育）肾皮质中的肾小球分布，与对照品系（LEW/Ztm）在10至150日龄之间的肾小球分布进行了比较。虽然这两个品系在身体生长、肾脏重量或肾皮质生长方面没有显著差异，但60日龄以上的MWF品系大鼠中，鲍曼囊和肾小球丛的平均直径显著更大（约12%）。在所有年龄组的MWF大鼠肾脏组织切片中，发现许多肾小球与肾被膜直接接触；因此，这一发育阶段肯定在10日龄之前就已发生。浅表性肾小球的出现是由于肾小球向肾表面正下方的位置——被膜下区或“皮质皮质”（通常没有肾小球）移动所致。对于肾皮质的其余部分，这两个品系之间在肾小球密度和每切片肾小球总数方面只有细微差异。这些结果使我们推测浅表性肾小球属于一种特殊的肾单位类型；因此，这些肾小球没有被近端小管的部分所包绕。
