Whitehouse M W, Rainsford K D
Toxicol Appl Pharmacol. 1983 Apr;68(2):323-7. doi: 10.1016/0041-008x(83)90016-9.
Oral or parenteral administration of lithium salts considerably increased the gastric fluid volume in rats, effectively preventing the hemorrhagic effects of oral or parenteral aspirin and other nonsteroid anti-inflammatory drugs on the gastric mucosa in cold-stressed and fasted animals and in fasted arthritic rats. The doses of Li+ which were totally protective in normal rats, though active, were much less protective in the arthritic animals. Thiocyanate salts reduced the gastrotoxicity of these drugs only in normal (i.e., nonarthritic) rats.
口服或肠胃外给予锂盐可显著增加大鼠胃液量，有效预防口服或肠胃外给予阿司匹林及其他非甾体抗炎药对冷应激和禁食动物以及禁食关节炎大鼠胃黏膜的出血作用。锂离子剂量在正常大鼠中具有完全保护作用，尽管有活性，但在关节炎动物中的保护作用要小得多。硫氰酸盐仅在正常（即非关节炎）大鼠中降低这些药物的胃毒性。
