Huang Y S, Drummond R, Horrobin D F
Digestion. 1987;36(1):36-41. doi: 10.1159/000199396.
The effects of feeding with gamma-linolenic acid (GLA) in comparison with linoleic acid on aspirin-induced gastric hemorrhage were studied in the rat. Gastric damage was examined macroscopically and histologically. Intragastric administration of 100 mg aspirin daily for 4 weeks produced hemorrhage in 3 of 8 rats receiving a linoleic-acid-enriched diet, but none in 8 rats receiving GLA-enriched diet. The levels of linoleic acid in plasma and liver phospholipids were significantly increased, whereas those of arachidonic acid (AA) were reduced in plasma and liver phospholipids of aspirin-treated animals fed linoleic acid. Similar, more pronounced changes occurred in those animals with hemorrhage. The reduced ratios of arachidonate/linoleate suggest that fatty acid desaturation in these animals was depressed. Treatment with GLA prevented these changes. Our results demonstrated that GLA could protect the gastric mucosa from aspirin-induced damage by bypassing the depressed delta-6-desaturation and thus providing a precursor for the synthesis of AA and prostaglandins.
在大鼠中研究了与亚油酸相比，喂食γ-亚麻酸（GLA）对阿司匹林诱导的胃出血的影响。通过宏观和组织学检查胃损伤情况。每天给大鼠胃内注射100毫克阿司匹林，持续4周，在8只接受富含亚油酸饮食的大鼠中，有3只出现出血，但在8只接受富含GLA饮食的大鼠中，无一出现出血。在喂食亚油酸的阿司匹林处理动物的血浆和肝脏磷脂中，亚油酸水平显著升高，而花生四烯酸（AA）水平降低。在出现出血的动物中，发生了类似但更明显的变化。花生四烯酸/亚油酸比例降低表明这些动物的脂肪酸去饱和作用受到抑制。用GLA治疗可防止这些变化。我们的结果表明，GLA可以绕过受抑制的δ-6-去饱和作用，从而为AA和前列腺素的合成提供前体，保护胃黏膜免受阿司匹林诱导的损伤。
